CDKN1A/p21 Polyclonal Antibody, Biotin Conjugated, Rabbit

Product Overview

• Article Name: CDKN1A/p21 Polyclonal Antibody, Biotin Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-0741R-BIOTIN
• Supplier Catalog Number: bs-0741R-Biotin
• Alternative Catalog Number: BSS-BS-0741R-BIOTIN-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IHC-Fr, IHC-P, WB
• Species Reactivity: Human, Mouse, Rat
• Conjugation: Biotin
• Alternative Names: P21, CDKI, CIP1, SDI1, Waf1, mda6, CAP2, Cdkn1, p21WAF, p21Cip1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, Cdkn1a

Product Description

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 12575
• UniProt: P38936
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human CDKN1A
• Target: CDKN1A/p21

Application Notes

• Application Dilute: WB(1:300-5000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500)