DNA Ligase IV Polyclonal Antibody, FITC Conjugated, Rabbit
Artikelnummer:
BSS-BS-1677R-FITC
Hersteller Artikelnummer:
bs-1677R-FITC
Alternativnummer:
BSS-BS-1677R-FITC-100
Hersteller:
Bioss
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, WB
Spezies Reaktivität:
Human
Konjugation:
FITC
Alternative Synonym:
LIG4S, DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, LIG4
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
