DNA Ligase IV Polyclonal Antibody, FITC Conjugated, Rabbit
Biozol Catalog Number:
BSS-BS-1677R-FITC
Supplier Catalog Number:
bs-1677R-FITC
Alternative Catalog Number:
BSS-BS-1677R-FITC-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
IF, WB
Species Reactivity:
Human
Conjugation:
FITC
Alternative Names:
LIG4S, DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, LIG4
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
