Recombinant SARS-CoV-2 Papain-Like Protease, N-His, Unconjugated

Produktübersicht

• Artikelname: Recombinant SARS-CoV-2 Papain-Like Protease, N-His, Unconjugated
• Artikelnummer: BSS-BS-41432P
• Hersteller Artikelnummer: bs-41432P
• Alternativnummer: BSS-BS-41432P-20,BSS-BS-41432P-100,BSS-BS-41432P-500
• Hersteller: Bioss
• Kategorie: Proteine/Peptide
• Applikation: ELISA
• Spezies Reaktivität: Other
• Konjugation: Unconjugated
• Alternative Synonym: sars-cov-2

Produktbeschreibung

Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits, specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.

Produkteigenschaften

• Tag: N-His
• NCBI: 43740578
• UniProt: P0DTD1
• Puffer: 0.01M TBS(pH7.4)
• Quelle: Recombinant SARS-CoV-2 Papain-Like Protease, N-His protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1564-1880/7096.
• Expression System: E.coli
• Reinheit: > 90% as determined by SDS- PAGE