Recombinant SARS-CoV-2 Papain-Like Protease, N-His, Unconjugated
Catalog Number:
BSS-BS-41432P
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| Article Name: | Recombinant SARS-CoV-2 Papain-Like Protease, N-His, Unconjugated |
| Biozol Catalog Number: | BSS-BS-41432P |
| Supplier Catalog Number: | bs-41432P |
| Alternative Catalog Number: | BSS-BS-41432P-20,BSS-BS-41432P-100,BSS-BS-41432P-500 |
| Manufacturer: | Bioss |
| Category: | Proteine/Peptide |
| Application: | ELISA |
| Species Reactivity: | Other |
| Conjugation: | Unconjugated |
| Alternative Names: | sars-cov-2 |
| Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits, specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons. |
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