Recombinant human RIPK1 protein, N-His, Unconjugated

Produktübersicht

• Artikelname: Recombinant human RIPK1 protein, N-His, Unconjugated
• Artikelnummer: BSS-BS-42114P
• Hersteller Artikelnummer: bs-42114P
• Alternativnummer: BSS-BS-42114P-100,BSS-BS-42114P-500
• Hersteller: Bioss
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Other
• Konjugation: Unconjugated

Produktbeschreibung

Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via Lys-63-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

Produkteigenschaften

• Tag: N-His
• NCBI: 8737
• UniProt: Q13546
• Puffer: 20mM Tris (pH8.0) with 8M Urea.
• Quelle: Recombinant human RIPK1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 327-564/671
• Expression System: E.coli
• Reinheit: > 90% as determined by SDS- PAGE