Recombinant human RIPK1 protein, N-His, Unconjugated

Product Overview

• Article Name: Recombinant human RIPK1 protein, N-His, Unconjugated
• Biozol Catalog Number: BSS-BS-42114P
• Supplier Catalog Number: bs-42114P
• Alternative Catalog Number: BSS-BS-42114P-100,BSS-BS-42114P-500
• Manufacturer: Bioss
• Category: Proteine/Peptide
• Species Reactivity: Other
• Conjugation: Unconjugated

Product Description

Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via Lys-63-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

Product Properties

• Tag: N-His
• NCBI: 8737
• UniProt: Q13546
• Buffer: 20mM Tris (pH8.0) with 8M Urea.
• Source: Recombinant human RIPK1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 327-564/671
• Expression System: E.coli
• Purity: > 90% as determined by SDS- PAGE