UNC2170, Methyl-lysine Binding Protein 53BP1 Inhibitor, CAS [[2173992-60-2]], Unconjugated

Produktübersicht

• Artikelname: UNC2170, Methyl-lysine Binding Protein 53BP1 Inhibitor, CAS [[2173992-60-2]], Unconjugated
• Artikelnummer: BSS-BS-60260C
• Hersteller Artikelnummer: bs-60260C
• Alternativnummer: BSS-BS-60260C-10,BSS-BS-60260C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

UNC2170 is a selective and cell permeable methyl-lysine binding protein 53BP1 antagonist with micromolar activity. It displays >17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested. Structural studies revealed that the tert-butyl amine of UNC2170 anchors the compound in the methyl-lysine (Kme) binding pocket of 53BP1, making it competitive with endogenous Kme substrates. X-ray crystallography also demonstrated that UNC2170 binds at the interface of two tudor domains of a 53BP1 dimer. It functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [2173992-60-2]