UNC2170, Methyl-lysine Binding Protein 53BP1 Inhibitor, CAS [[2173992-60-2]], Unconjugated

Product Overview

• Article Name: UNC2170, Methyl-lysine Binding Protein 53BP1 Inhibitor, CAS [[2173992-60-2]], Unconjugated
• Biozol Catalog Number: BSS-BS-60260C
• Supplier Catalog Number: bs-60260C
• Alternative Catalog Number: BSS-BS-60260C-10,BSS-BS-60260C-2
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

UNC2170 is a selective and cell permeable methyl-lysine binding protein 53BP1 antagonist with micromolar activity. It displays >17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested. Structural studies revealed that the tert-butyl amine of UNC2170 anchors the compound in the methyl-lysine (Kme) binding pocket of 53BP1, making it competitive with endogenous Kme substrates. X-ray crystallography also demonstrated that UNC2170 binds at the interface of two tudor domains of a 53BP1 dimer. It functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.

Product Properties

• Buffer: Powder
• CAS Number: [2173992-60-2]