SirReal2, Sirt2 Inhibitor, CAS [[709002-46-0]], Unconjugated

Produktübersicht

• Artikelname: SirReal2, Sirt2 Inhibitor, CAS [[709002-46-0]], Unconjugated
• Artikelnummer: BSS-BS-60289C
• Hersteller Artikelnummer: bs-60289C
• Alternativnummer: BSS-BS-60289C-10,BSS-BS-60289C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 ~140 nM, has minimal effect on Sirt1 and Sirt3-6. It occupies the extended C-site and induces a major rearrangement of Sirt2s active site, so it selectively inhibits Sirt2 and functions as a molecular wedge to lock Sirt2 in an open conformation. SirReal2 can increase tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. It could be a useful chemical tool for sirtuin biology.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [709002-46-0]