SirReal2, Sirt2 Inhibitor, CAS [[709002-46-0]], Unconjugated
Biozol Catalog Number:
BSS-BS-60289C
Supplier Catalog Number:
bs-60289C
Alternative Catalog Number:
BSS-BS-60289C-10,BSS-BS-60289C-2
Manufacturer:
Bioss
Category:
Biochemikalien
Conjugation:
Unconjugated
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 ~140 nM, has minimal effect on Sirt1 and Sirt3-6. It occupies the extended C-site and induces a major rearrangement of Sirt2s active site, so it selectively inhibits Sirt2 and functions as a molecular wedge to lock Sirt2 in an open conformation. SirReal2 can increase tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. It could be a useful chemical tool for sirtuin biology.
Buffer:
Powder
CAS Number:
[709002-46-0]
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