GSK2879552, LSD1 Inhibitor, CAS [[1902123-72-1]], Unconjugated

Produktübersicht

• Artikelname: GSK2879552, LSD1 Inhibitor, CAS [[1902123-72-1]], Unconjugated
• Artikelnummer: BSS-BS-60297C
• Hersteller Artikelnummer: bs-60297C
• Alternativnummer: BSS-BS-60297C-10,BSS-BS-60297C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

GSK2879552 is a highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It is highly selective over related enzymes such as MAO-A/B. A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to GSK2879552s inhibition. It increases H3K4 methylation selectively at genomic regions bound by LSD1. It demonstrates efficacy in preclinical models of SCLC. Currently GSK2879552 is in phase I clinical trials targeting Acute Myeloid Leukemia (AML) and Relapsed/Refractory Small Cell Lung Carcinoma.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [1902123-72-1]