GSK2879552, LSD1 Inhibitor, CAS [[1902123-72-1]], Unconjugated

Product Overview

• Article Name: GSK2879552, LSD1 Inhibitor, CAS [[1902123-72-1]], Unconjugated
• Biozol Catalog Number: BSS-BS-60297C
• Supplier Catalog Number: bs-60297C
• Alternative Catalog Number: BSS-BS-60297C-10,BSS-BS-60297C-2
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

GSK2879552 is a highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It is highly selective over related enzymes such as MAO-A/B. A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to GSK2879552s inhibition. It increases H3K4 methylation selectively at genomic regions bound by LSD1. It demonstrates efficacy in preclinical models of SCLC. Currently GSK2879552 is in phase I clinical trials targeting Acute Myeloid Leukemia (AML) and Relapsed/Refractory Small Cell Lung Carcinoma.

Product Properties

• Buffer: Powder
• CAS Number: [1902123-72-1]