MRT68921, Autophagy Kinase ULK1/2 Inhibitor, CAS [[1190378-57-4]], Unconjugated

Produktübersicht

• Artikelname: MRT68921, Autophagy Kinase ULK1/2 Inhibitor, CAS [[1190378-57-4]], Unconjugated
• Artikelnummer: BSS-BS-60311C
• Hersteller Artikelnummer: bs-60311C
• Alternativnummer: BSS-BS-60311C-10,BSS-BS-60311C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

MRT68921 is a potent, selective and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. It can inhibit ULK in vitro and block autophagy in cells. By generating the drug-resistant M92T ULK1 mutant, MRT68921demostrates to specifically block autophagic flux through ULK1 inhibition and disrupt autophagosome maturation, not through AMPK-related kinase involvement. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [1190378-57-4]