MRT68921, Autophagy Kinase ULK1/2 Inhibitor, CAS [[1190378-57-4]], Unconjugated
Biozol Catalog Number:
BSS-BS-60311C
Supplier Catalog Number:
bs-60311C
Alternative Catalog Number:
BSS-BS-60311C-10,BSS-BS-60311C-2
Manufacturer:
Bioss
Category:
Biochemikalien
Conjugation:
Unconjugated
MRT68921 is a potent, selective and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. It can inhibit ULK in vitro and block autophagy in cells. By generating the drug-resistant M92T ULK1 mutant, MRT68921demostrates to specifically block autophagic flux through ULK1 inhibition and disrupt autophagosome maturation, not through AMPK-related kinase involvement. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.
Buffer:
Powder
CAS Number:
[1190378-57-4]
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