HIF1AN Recombinant Antibody, PE Conjugated, Rabbit
Artikelnummer:
BSS-BSM-61905R-PE
Hersteller Artikelnummer:
bsm-61905R-PE
Alternativnummer:
BSS-BSM-61905R-PE-100
Hersteller:
Bioss
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, IF, WB
Spezies Reaktivität:
Human
Konjugation:
PE
Alternative Synonym:
FIH 1, FIH1, HIF1AN.
Hydroxylates HIF-1 alpha at Asn-803 in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.
