HIF1AN Recombinant Antibody, PE Conjugated, Rabbit
Biozol Catalog Number:
BSS-BSM-61905R-PE
Supplier Catalog Number:
bsm-61905R-PE
Alternative Catalog Number:
BSS-BSM-61905R-PE-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
FC, IF, WB
Species Reactivity:
Human
Conjugation:
PE
Alternative Names:
FIH 1, FIH1, HIF1AN.
Hydroxylates HIF-1 alpha at Asn-803 in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.
