Phospho-PML Protein (Ser518) Recombinant Rabbit mAb, Unconjugated
Artikelnummer:
BWT-BS43094
Hersteller Artikelnummer:
BS43094
Alternativnummer:
BWT-BS43094-50UL,BWT-BS43094-100UL
Hersteller:
Bioworld Technology
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human, Mouse
Immunogen:
A synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML Protein
Konjugation:
Unconjugated
Alternative Synonym:
MYL, RNF71, PP8675, TRIM19
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the proteins central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Store at -20C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Application Verdünnung:
WB: 1:1000<br />IHC: 1:50
Anwendungsbeschreibung:
IgG
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
