Phospho-PML Protein (Ser518) Recombinant Rabbit mAb, Unconjugated
Biozol Catalog Number:
BWT-BS43094
Supplier Catalog Number:
BS43094
Alternative Catalog Number:
BWT-BS43094-50UL,BWT-BS43094-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human, Mouse
Immunogen:
A synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML Protein
Conjugation:
Unconjugated
Alternative Names:
MYL, RNF71, PP8675, TRIM19
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the proteins central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Store at -20C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Application Dilute:
WB: 1:1000<br />IHC: 1:50
Application Notes:
IgG
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