IL3RA polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: IL3RA polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS60620
• Hersteller Artikelnummer: BS60620
• Alternativnummer: BWT-BS60620-50UL,BWT-BS60620-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to Human IL3RA.
• Konjugation: Unconjugated
• Alternative Synonym: Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, CD_antigen: CD123

Produktbeschreibung

IL3RA/CD123 is the alpha subunit of an IL-3 receptor that also contains the common beta chain (betac) shared with receptors for other cytokines. IL3RA/CD123 alone binds to IL-3 with high specificity but low affinity and it does not transduce intracellular signaling, while betac alone does not bind to IL-3 appreciably. Together, IL3RA/CD123 and betac form the functional high-affinity receptor for IL-3. IL3RA/CD123 is mainly expressed on the hematopoietic progenitor cells, primarily the granulocytic and monocytic linages . IL3RA/CD123 is highly expressed on leukemic stem cells in the majority of AML (acute myeloid leukemia) patients and is correlated with poor prognosis. In addition, overexpression of IL3RA/CD123 has also been reported for other hematopoietic malignancies. It is considered as a valuable therapeutic target for these malignancies.

Produkteigenschaften

• Molekulargewicht: ~ 60 kDa
• UniProt: P26951
• Reinheit: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Formulierung: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Anwendungsbeschreibung

• Application Verdünnung: WB: 1:1000~1:2000
• Anwendungsbeschreibung: IL3RA polyclonal antibody detects endogenous levels of IL3RA protein.