IL3RA polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: IL3RA polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS60620
• Supplier Catalog Number: BS60620
• Alternative Catalog Number: BWT-BS60620-50UL,BWT-BS60620-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to Human IL3RA.
• Conjugation: Unconjugated
• Alternative Names: Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, CD_antigen: CD123

Product Description

IL3RA/CD123 is the alpha subunit of an IL-3 receptor that also contains the common beta chain (betac) shared with receptors for other cytokines. IL3RA/CD123 alone binds to IL-3 with high specificity but low affinity and it does not transduce intracellular signaling, while betac alone does not bind to IL-3 appreciably. Together, IL3RA/CD123 and betac form the functional high-affinity receptor for IL-3. IL3RA/CD123 is mainly expressed on the hematopoietic progenitor cells, primarily the granulocytic and monocytic linages . IL3RA/CD123 is highly expressed on leukemic stem cells in the majority of AML (acute myeloid leukemia) patients and is correlated with poor prognosis. In addition, overexpression of IL3RA/CD123 has also been reported for other hematopoietic malignancies. It is considered as a valuable therapeutic target for these malignancies.

Product Properties

• Molecular Weight: ~ 60 kDa
• UniProt: P26951
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Application Notes

• Application Dilute: WB: 1:1000~1:2000
• Application Notes: IL3RA polyclonal antibody detects endogenous levels of IL3RA protein.