Angiotensin II type 1A receptor polyclonal antibody, Unconjugated, Rabbit
Artikelnummer:
BWT-BS65523
Hersteller Artikelnummer:
BS65523
Alternativnummer:
BWT-BS65523-50UL,BWT-BS65523-100UL
Hersteller:
Bioworld Technology
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
KLH conjugated synthetic peptide derived from human Angiotensin II type 1A receptor:101-200/359
Konjugation:
Unconjugated
Alternative Synonym:
AGTR1, Agtr1a, AT1, AT1A, AT1AR, Type 1 angiotensin II receptor, AGTR1_HUMAN, AGTR1B, AT2R1, AT2R1B.
The Angiotensin II type 1 receptor (AT1) is the primary effector of Angiotensin II, a key regulator of blood pressure and fluid homeostasis. It is involved in pathogenesis of several cardiovascular diseases such as hypertension, cardiac hypertrophy and congestive heart failure. Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and AT2 (type 2). AT1 has three isoforms in rodents: AT1A (359 aa), AT1B (359 aa), and AT1C (177 aa). Rat AT1s are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellular, while the C-terminus is predicted to be cytoplasmic. AT1s are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle.
