Angiotensin II type 1A receptor polyclonal antibody, Unconjugated, Rabbit
Biozol Catalog Number:
BWT-BS65523
Supplier Catalog Number:
BS65523
Alternative Catalog Number:
BWT-BS65523-50UL,BWT-BS65523-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
KLH conjugated synthetic peptide derived from human Angiotensin II type 1A receptor:101-200/359
Conjugation:
Unconjugated
Alternative Names:
AGTR1, Agtr1a, AT1, AT1A, AT1AR, Type 1 angiotensin II receptor, AGTR1_HUMAN, AGTR1B, AT2R1, AT2R1B.
The Angiotensin II type 1 receptor (AT1) is the primary effector of Angiotensin II, a key regulator of blood pressure and fluid homeostasis. It is involved in pathogenesis of several cardiovascular diseases such as hypertension, cardiac hypertrophy and congestive heart failure. Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and AT2 (type 2). AT1 has three isoforms in rodents: AT1A (359 aa), AT1B (359 aa), and AT1C (177 aa). Rat AT1s are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellular, while the C-terminus is predicted to be cytoplasmic. AT1s are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle.
