Recombinant Human Stromal-Cell Derived Factor-1beta/CXCL12 (rHuSDF-1b/CXCL12)
Artikelnummer:
BWT-PR1116
Hersteller Artikelnummer:
PR1116
Alternativnummer:
BWT-PR1116-2UG,BWT-PR1116-10UG,BWT-PR1116-1.0MG
Hersteller:
Bioworld Technology
Kategorie:
Proteine/Peptide
Stromal-Cell Derived Factor-1 beta (SDF1beta), also known as SCYB12, PBSF and CXCL12, is an 8.3 kDa, heparin-binding member of the CXC (or alpha) family of chemokines and signal through the CXCR4 receptor. SDF1alpha and beta are reported to be monomers at neutral pH and physiologic ionic strength, On the cell surface, this may well facilitate SDF1 interaction with its two receptors, CXCR4 and syndecan4. Heparin sulfate is known to protect SDF1 from proteolysis, and CXCR4 exists constitutively as a dimer. Among its many functions, CXCL12 is known to influence lymphopoiesis, regulate patterning and cell number of neural progenitors, and promote angiogenesis (12, 13). It also enhances the survival of myeloid progenitor cells.
Molekulargewicht:
Approximately 8.5 kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.
Quelle:
Escherichia coli.
Reinheit:
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRF KM
Formulierung:
Measured by its ability to chemoattract human CXCR4 transfected BaF3 mouse proB cells. The ED50 for this effect is typically 1-5 ng/mL.
Sequenz:
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
Formel:
Sterile Filtered White lyophilized (freeze-dried) powder.
Anwendungsbeschreibung:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
