Recombinant Human Stromal-Cell Derived Factor-1beta/CXCL12 (rHuSDF-1b/CXCL12)
Biozol Catalog Number:
BWT-PR1116
Supplier Catalog Number:
PR1116
Alternative Catalog Number:
BWT-PR1116-2UG,BWT-PR1116-10UG,BWT-PR1116-1.0MG
Manufacturer:
Bioworld Technology
Category:
Proteine/Peptide
Stromal-Cell Derived Factor-1 beta (SDF1beta), also known as SCYB12, PBSF and CXCL12, is an 8.3 kDa, heparin-binding member of the CXC (or alpha) family of chemokines and signal through the CXCR4 receptor. SDF1alpha and beta are reported to be monomers at neutral pH and physiologic ionic strength, On the cell surface, this may well facilitate SDF1 interaction with its two receptors, CXCR4 and syndecan4. Heparin sulfate is known to protect SDF1 from proteolysis, and CXCR4 exists constitutively as a dimer. Among its many functions, CXCL12 is known to influence lymphopoiesis, regulate patterning and cell number of neural progenitors, and promote angiogenesis (12, 13). It also enhances the survival of myeloid progenitor cells.
Molecular Weight:
Approximately 8.5 kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.
Source:
Escherichia coli.
Purity:
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRF KM
Form:
Measured by its ability to chemoattract human CXCR4 transfected BaF3 mouse proB cells. The ED50 for this effect is typically 1-5 ng/mL.
Sequence:
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
Formula:
Sterile Filtered White lyophilized (freeze-dried) powder.
Application Notes:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
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