Navtemadlin, CAS [[1352066-68-2]]

Produktübersicht

• Artikelname: Navtemadlin, CAS [[1352066-68-2]]
• Artikelnummer: BYT-ORB1296183
• Hersteller Artikelnummer: orb1296183
• Alternativnummer: BYT-ORB1296183-1, BYT-ORB1296183-10, BYT-ORB1296183-100, BYT-ORB1296183-2, BYT-ORB1296183-25, BYT-ORB1296183-5, BYT-ORB1296183-50
• Hersteller: Biorbyt
• Kategorie: Biochemikalien
• Alternative Synonym: Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme, AMG232, AMG-232, AMG 232, CS1300, CS-1300, CS 1300, E2 Enzyme, E2 conjugating enzyme, E1Enzyme, E1/E2/E3 Enzyme, E1 activating enzyme, E1 Enzyme, E2Enzyme, E3 Enzyme, MDM-2/p53, MDM2, Inhibitor, E3Enzyme, E3 ligating enzyme, KRT 232, KRT232, KRT-232, inhibit, p53-MDM2, Navtemadlin

Produktbeschreibung

Navtemadlin (AMG-232) is a highly potent and selective oral inhibitor of the p53-MDM2 interaction, exhibiting an IC50 of 0.6 nM and a Kd of 0.045 nM for MDM2. It is widely used in cancer research to reactivate p53 pathways, demonstrating antitumor efficacy in both in vitro cellular assays and in vivo xenograft models.

Produkteigenschaften

• Molekulargewicht: 568.55
• Reinheit: 99.08% (May vary between batches)
• CAS Nummer: [1352066-68-2]
• Formel: C28H35Cl2NO5S
• Target-Kategorie: Mdm2,MDM-2/p53,E1/E2/E3 Enzyme

Anwendungsbeschreibung

• Anwendungsbeschreibung: Solubility: DMSO:150 mg/mL (263.83 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.52 mM),H2O:Insoluble