Navtemadlin, CAS [[1352066-68-2]]

Product Overview

• Article Name: Navtemadlin, CAS [[1352066-68-2]]
• Biozol Catalog Number: BYT-ORB1296183
• Supplier Catalog Number: orb1296183
• Alternative Catalog Number: BYT-ORB1296183-1, BYT-ORB1296183-10, BYT-ORB1296183-100, BYT-ORB1296183-2, BYT-ORB1296183-25, BYT-ORB1296183-5, BYT-ORB1296183-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme, AMG232, AMG-232, AMG 232, CS1300, CS-1300, CS 1300, E2 Enzyme, E2 conjugating enzyme, E1Enzyme, E1/E2/E3 Enzyme, E1 activating enzyme, E1 Enzyme, E2Enzyme, E3 Enzyme, MDM-2/p53, MDM2, Inhibitor, E3Enzyme, E3 ligating enzyme, KRT 232, KRT232, KRT-232, inhibit, p53-MDM2, Navtemadlin

Product Description

Navtemadlin (AMG-232) is a highly potent and selective oral inhibitor of the p53-MDM2 interaction, exhibiting an IC50 of 0.6 nM and a Kd of 0.045 nM for MDM2. It is widely used in cancer research to reactivate p53 pathways, demonstrating antitumor efficacy in both in vitro cellular assays and in vivo xenograft models.

Product Properties

• Molecular Weight: 568.55
• Purity: 99.08% (May vary between batches)
• CAS Number: [1352066-68-2]
• Formula: C28H35Cl2NO5S
• Target: Mdm2,MDM-2/p53,E1/E2/E3 Enzyme

Application Notes

• Application Notes: Solubility: DMSO:150 mg/mL (263.83 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.52 mM),H2O:Insoluble