VH298, VH-298, VH 298, VHL, E3 ligase-recruiting Moiety, HIF-1alpha, Inhibitor, inhibit, Ligands for E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase
VH-298 is a cell-permeable small molecule that potently inhibits the VHL-HIF-alpha interaction, stabilizing HIF-alpha and inducing a hypoxic response independent of PHD enzyme inhibition. It is a valuable chemical probe for studying hypoxia signaling pathways and has demonstrated utility in both cellular assays and in vivo models for angiogenesis and ischemia research.
Molekulargewicht:
523.65
Reinheit:
>99.99% (May vary between batches)
CAS Nummer:
[2097381-85-4]
Formel:
C27H33N5O4S
Target-Kategorie:
HIF/HIF Prolyl-Hydroxylase,Ligands for E3 Ligase,HIF