VH-298, CAS [[2097381-85-4]]

Product Overview

• Article Name: VH-298, CAS [[2097381-85-4]]
• Biozol Catalog Number: BYT-ORB1296188
• Supplier Catalog Number: orb1296188
• Alternative Catalog Number: BYT-ORB1296188-1, BYT-ORB1296188-10, BYT-ORB1296188-100, BYT-ORB1296188-2, BYT-ORB1296188-25, BYT-ORB1296188-5, BYT-ORB1296188-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: VH298, VH-298, VH 298, VHL, E3 ligase-recruiting Moiety, HIF-1alpha, Inhibitor, inhibit, Ligands for E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase

Product Description

VH-298 is a cell-permeable small molecule that potently inhibits the VHL-HIF-alpha interaction, stabilizing HIF-alpha and inducing a hypoxic response independent of PHD enzyme inhibition. It is a valuable chemical probe for studying hypoxia signaling pathways and has demonstrated utility in both cellular assays and in vivo models for angiogenesis and ischemia research.

Product Properties

• Molecular Weight: 523.65
• Purity: >99.99% (May vary between batches)
• CAS Number: [2097381-85-4]
• Formula: C27H33N5O4S
• Target: HIF/HIF Prolyl-Hydroxylase,Ligands for E3 Ligase,HIF

Application Notes

• Application Notes: Solubility: DMSO:78.3 mg/mL (149.53 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.82 mM)