NCT-58 is a C-terminal HSP90 inhibitor that suppresses the HER family and Akt phosphorylation without triggering the heat shock response. It demonstrates anti-tumor efficacy by inducing apoptosis in HER2-positive cells and eliminating trastuzumab-resistant breast cancer stem-like cells in vitro.
Molekulargewicht:
466.57
Reinheit:
99.60% (May vary between batches)
CAS Nummer:
[2411429-33-7]
Formel:
C27H34N2O5
Target-Kategorie:
Apoptosis,HSP
Anwendungsbeschreibung:
Solubility: DMSO:40 mg/mL (85.73 mM)
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten