NCT-58 is a C-terminal HSP90 inhibitor that suppresses the HER family and Akt phosphorylation without triggering the heat shock response. It demonstrates anti-tumor efficacy by inducing apoptosis in HER2-positive cells and eliminating trastuzumab-resistant breast cancer stem-like cells in vitro.
Molecular Weight:
466.57
Purity:
99.60% (May vary between batches)
CAS Number:
[2411429-33-7]
Formula:
C27H34N2O5
Target:
Apoptosis,HSP
Application Notes:
Solubility: DMSO:40 mg/mL (85.73 mM)
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