Compound 53, an oxindole-based STING agonist, potently activates human STING with an EC50 of 185 nM in both primary and immortalized cells, eliciting a characteristic cytokine profile. This small molecule is a valuable tool for probing STING pathway immunobiology in vitro and has been utilized in preclinical in vivo studies for cancer immunotherapy research.
Molekulargewicht:
490.88
Reinheit:
98.29% (May vary between batches)
CAS Nummer:
[2259624-71-8]
Formel:
C25H19ClF4N2O2
Target-Kategorie:
STING
Anwendungsbeschreibung:
Solubility: DMSO:60 mg/mL (122.23 mM)
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