cancer, DNA Methyltransferase, DNA MTases, DNAMethyltransferase, DNMT1, DNMTs, GSK3685032, GSK-3685032, GSK 3685032, leukemia, GDM-1, lymphoma, Inhibitor, inhibit, multiple myeloma, MV4-11
GSK3685032 is a potent, selective, and reversible non-covalent inhibitor of DNMT1 (IC50 = 36 nM). It induces DNA demethylation and gene reactivation, demonstrating robust anti-proliferative effects in cancer cell lines and in vivo tumor models, making it a valuable tool for epigenetic and oncology research.