Inhibitor, leucyl-tRNA synthetase, Leucyl-tRNA synthetase, H460, lung cancer, KRAS G12D, inhibit, A549, 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide, BC LI 0186, BC-LI 0186, BCLI0186, BC-LI0186, BC-LI-0186, Aminoacyl-tRNA Synthetase, RagD, rapamycin-resistant, Ras-related GTP-binding protein D (RagD), tRNA Synthetase, aaRS
BC-LI-0186 is a potent, selective inhibitor of the LRS-RagD interaction with a Kd of 42.1 nM. It suppresses mTORC1 signaling by this mechanism, inhibiting the growth of rapamycin-resistant cancer cells in vitro, and is applied in lung cancer research.