HPK1-IN-7 is an orally bioavailable, small molecule inhibitor of Hematopoietic Progenitor Kinase 1. It demonstrates selectivity over related kinases IRAK4 (IC50 = 59 nM) and GLK (IC50 = 140 nM). This compound is a valuable research tool for investigating HPK1 function in immune cell signaling and for preclinical studies in immuno-oncology.