SKI-178, CAS [[1259484-97-3]]

Produktübersicht

• Artikelname: SKI-178, CAS [[1259484-97-3]]
• Artikelnummer: BYT-ORB1298446
• Hersteller Artikelnummer: orb1298446
• Alternativnummer: BYT-ORB1298446-1, BYT-ORB1298446-10, BYT-ORB1298446-100, BYT-ORB1298446-2, BYT-ORB1298446-25, BYT-ORB1298446-5, BYT-ORB1298446-50, BYT-ORB1298446-500
• Hersteller: Biorbyt
• Kategorie: Biochemikalien
• Alternative Synonym: myeloid, multi-drug, inhibit, Inhibitor, leukemia, cell, drug, cytotoxic, cancer, Apoptosis, sensitive, S1P Receptor, S1PReceptor, resistant, SphK1, SphK2, SphK, Sphingosine kinase, SKI 178, SKI178, SKI-178

Produktbeschreibung

SKI-178 is a potent SphK1 inhibitor (IC50 0.1-1.8 µM) that triggers prolonged mitosis and intrinsic apoptosis. This effect is mediated by sustained CDK1 activity, which phosphorylates Bcl-2 and Bcl-xL while degrading Mcl-1. It serves as a valuable chemical probe for studying sphingolipid signaling, cell cycle arrest, and apoptosis in cancer research models.

Produkteigenschaften

• Molekulargewicht: 394.42
• Reinheit: 99.20% (May vary between batches)
• CAS Nummer: [1259484-97-3]
• Formel: C21H22N4O4
• Target-Kategorie: Apoptosis,S1P Receptor

Anwendungsbeschreibung

• Anwendungsbeschreibung: Solubility: DMSO:50 mg/mL (126.77 mM),10% DMSO+90% Corn Oil:2.5 mg/mL (6.34 mM)