SKI-178, CAS [[1259484-97-3]]

Product Overview

• Article Name: SKI-178, CAS [[1259484-97-3]]
• Biozol Catalog Number: BYT-ORB1298446
• Supplier Catalog Number: orb1298446
• Alternative Catalog Number: BYT-ORB1298446-1, BYT-ORB1298446-10, BYT-ORB1298446-100, BYT-ORB1298446-2, BYT-ORB1298446-25, BYT-ORB1298446-5, BYT-ORB1298446-50, BYT-ORB1298446-500
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: myeloid, multi-drug, inhibit, Inhibitor, leukemia, cell, drug, cytotoxic, cancer, Apoptosis, sensitive, S1P Receptor, S1PReceptor, resistant, SphK1, SphK2, SphK, Sphingosine kinase, SKI 178, SKI178, SKI-178

Product Description

SKI-178 is a potent SphK1 inhibitor (IC50 0.1-1.8 µM) that triggers prolonged mitosis and intrinsic apoptosis. This effect is mediated by sustained CDK1 activity, which phosphorylates Bcl-2 and Bcl-xL while degrading Mcl-1. It serves as a valuable chemical probe for studying sphingolipid signaling, cell cycle arrest, and apoptosis in cancer research models.

Product Properties

• Molecular Weight: 394.42
• Purity: 99.20% (May vary between batches)
• CAS Number: [1259484-97-3]
• Formula: C21H22N4O4
• Target: Apoptosis,S1P Receptor

Application Notes

• Application Notes: Solubility: DMSO:50 mg/mL (126.77 mM),10% DMSO+90% Corn Oil:2.5 mg/mL (6.34 mM)