Topo II, Topoisomerase, Protein kinase C, PKC, Apoptosis, antitumor, B-CLL cells, breast cancer, NSC-301739, NSC301739, lymphocytes, Mitoxantrone, mitozantrone, Orthopoxvirus, NSC 301739, inhibit, Inhibitor, HL60 cells, MCF-7, leukaemia, Endogenous Metabolite
Mitoxantrone is a dual Topo II and PKC inhibitor (IC50=8.5 µM) with established antitumor activity. It is widely used in research models for leukemia, breast cancer, and hepatocellular carcinoma, supporting both in vitro mechanistic studies and in vivo efficacy experiments.