E6446, E-6446, E6446 dihydrochloride, E6446 Dihydrochloride, E-6446 Dihydrochloride, E-6446 dihydrochloride, E 6446, E 6446 Dihydrochloride, TLR
E6446 dihydrochloride is a potent and selective synthetic antagonist of nucleic acid-sensing Toll-like receptors (TLRs). It inhibits DNA-induced TLR9 signaling in HEK293 cells with an IC50 of 10 nM, making it a valuable tool for studying innate immune pathways in vitro and in vivo models of autoimmune and inflammatory diseases.
Molekulargewicht:
522.51
Reinheit:
99.44% (May vary between batches)
CAS Nummer:
[1345675-25-3]
Formel:
C27H37Cl2N3O3
Target-Kategorie:
TLR,Stearoyl-CoA Desaturase (SCD)
Anwendungsbeschreibung:
Solubility: DMSO:5.23 mg/mL (10.01 mM)
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten