E6446 dihydrochloride, CAS [[1345675-25-3]]

Product Overview

• Article Name: E6446 dihydrochloride, CAS [[1345675-25-3]]
• Biozol Catalog Number: BYT-ORB1303204
• Supplier Catalog Number: orb1303204
• Alternative Catalog Number: BYT-ORB1303204-1, BYT-ORB1303204-1, BYT-ORB1303204-10, BYT-ORB1303204-100, BYT-ORB1303204-2, BYT-ORB1303204-25, BYT-ORB1303204-5, BYT-ORB1303204-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: E6446, E-6446, E6446 dihydrochloride, E6446 Dihydrochloride, E-6446 Dihydrochloride, E-6446 dihydrochloride, E 6446, E 6446 Dihydrochloride, TLR

Product Description

E6446 dihydrochloride is a potent and selective synthetic antagonist of nucleic acid-sensing Toll-like receptors (TLRs). It inhibits DNA-induced TLR9 signaling in HEK293 cells with an IC50 of 10 nM, making it a valuable tool for studying innate immune pathways in vitro and in vivo models of autoimmune and inflammatory diseases.

Product Properties

• Molecular Weight: 522.51
• Purity: 99.44% (May vary between batches)
• CAS Number: [1345675-25-3]
• Formula: C27H37Cl2N3O3
• Target: TLR,Stearoyl-CoA Desaturase (SCD)

Application Notes

• Application Notes: Solubility: DMSO:5.23 mg/mL (10.01 mM)