Ro 67-7476 is a potent and selective positive allosteric modulator of rat mGluR1a (EC50 = 60.1 nM), enhancing glutamate-induced calcium release. It also acts as a P-ERK1/2 agonist, independently stimulating ERK1/2 phosphorylation (EC50 = 163.3 nM). This compound is a valuable research tool for studying mGluR1 signaling in neurological disease models, both in vitro and in vivo.
Molekulargewicht:
319.39
Reinheit:
99.69% (May vary between batches)
CAS Nummer:
[298690-60-5]
Formel:
C17H18FNO2S
Target-Kategorie:
GluR
Anwendungsbeschreibung:
Solubility: DMSO:50 mg/mL (156.55 mM)
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