Cynomolgus IL-23 R Protein, Unconjugated Preis auf Anfrage

Produktübersicht

• Artikelname: Cynomolgus IL-23 R Protein, Unconjugated Preis auf Anfrage
• Artikelnummer: BYT-ORB1496206
• Hersteller Artikelnummer: orb1496206
• Alternativnummer: BYT-ORB1496206-1,BYT-ORB1496206-100
• Hersteller: Biorbyt
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Monkey
• Konjugation: Unconjugated
• Alternative Synonym: IL-23 R,IL-23 Receptor

Produktbeschreibung

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Produkteigenschaften

• Molekulargewicht: 64.5 kDa
• NCBI: 7
• UniProt: G7NWY5
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Liquid
• Target-Kategorie: IL-23 R

Anwendungsbeschreibung

• Anwendungsbeschreibung: Application Notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation

Bilder

Immobilized Biotinylated Human IL-23A & IL-12B Heterodimer Protein, His, Avitag & Tag Free at 1 µg/mL (100 µL/well) on streptavidin (Cat. No. orb668907) precoated (0.5 µg/well) plate can bind Cynomolgus IL-23 R, Fc Tag (Cat. No. orb1496206) with a linear range of 0.1-3 ng/mL (QC tested).