LSKL, Inhibitor of Thrombospondin (TSP 1) (TFA), LSKL, Inhibitor of Thrombospondin (TSP-1), LSKL, Inhibitor of Thrombospondin (TSP1) (TFA), LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA), H-Leu-Ser-Lys-Leu-NH2 TFA, H-Leu-Ser-Lys-Leu-NH2 TFA(283609-79-0 TFA), TGF-beta1, TGF-beta/Smad, TGF-beta Receptor, TGFbeta, TGFbeta/Smad, TGF-b/Smad, TGFb, TGFbeta, TGF-beta, Smad
LSKL TFA is a blood-brain barrier permeable TGF-beta1 antagonist derived from LAP. It functions by inhibiting the TSP-1/LAP interaction, thereby blocking TGF-beta1 activation. This mechanism has demonstrated efficacy in preclinical models of subarachnoid hemorrhage, renal fibrosis, and liver fibrosis.