Mammalian target of Rapamycin, Inhibitor, mTOR, inhibit, Src, WAY 600, PI3Kgamma, PI3Kalpha, WAY600, WAY-600, VEGFR2
WAY-600 is a potent and selective ATP-competitive mTOR inhibitor with an IC50 of 9 nM. It effectively suppresses both mTORC1 and mTORC2 signaling by inhibiting phosphorylation of S6K(T389) and AKT(S473), respectively, and demonstrates high selectivity over PI3K isoforms. This inhibitor is a valuable tool for studying mTOR-dependent pathways in cancer and metabolic disease research, applicable in both cellular and in vivo models.