imatinib-resistant, leukemia, Inhibitor, inhibit, myeloid, AKI 603, AKI603, AKI-603, Aurora A, AuroraKinase, Aurora Kinase, CML, chronic
AKI603 is a potent and selective Aurora kinase A (AurA) inhibitor with an IC50 of 12.3 nM. It was developed to target BCR-ABL-T315I mutation-driven resistance, demonstrating robust anti-proliferative effects in leukemic cell lines in vitro and showing potential for leukemia research.
Molekulargewicht:
409.45
Reinheit:
99.81% (May vary between batches)
CAS Nummer:
[1432515-73-5]
Formel:
C19H23N9O2
Target-Kategorie:
Aurora Kinase
Anwendungsbeschreibung:
Solubility: DMSO:120 mg/mL (293.08 mM)
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten