Antileukinate is an acetylated, amidated hexapeptide antagonist of the CXCR2 chemokine receptor. It blocks IL-8 binding and neutrophil activation in vitro (Ki = 2.7-13 µM) and demonstrates protective effects in vivo, such as reducing acute pancreatitis and associated lung injury in mouse models at 53 mg/kg.
Molekulargewicht:
1003.19
CAS Nummer:
[138559-60-1]
Formel:
C45H66N18O7S
Target-Kategorie:
CXCR
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