6(5H)-Phenanthridinone is a dual PARP1/PARP2 inhibitor that suppresses radiation-induced proliferation in murine lymphoma cells and reduces pro-inflammatory cytokine expression in lymphocytes. In vivo, it ameliorates EAE in rats by decreasing spinal cord iNOS and cytokine levels, while also reducing hepatic oxidative damage and serum LDH.
Molekulargewicht:
195.22
CAS Nummer:
[1015-89-0]
Formel:
C13H9NO
Target-Kategorie:
PARP,Others
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