PD-321852 is a selective Chk1 inhibitor that enhances gemcitabine cytotoxicity in pancreatic cancer models, as demonstrated by in vitro studies showing synergistic chemosensitization and loss of Chk1 protein. This compound is a valuable research tool for investigating DNA damage response pathways and combination chemotherapy strategies.
Molekulargewicht:
468.33
CAS Nummer:
[622856-21-7]
Formel:
C24H19Cl2N3O3
Target-Kategorie:
Chk,Others
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