HDAC4 CHDI Degrader 11 is a potent and selective PROTAC degrader of HDAC4, demonstrating low nanomolar DC50 values in Jurkat and Huntingtons disease model cells. Its bifunctional design links a class IIa HDAC inhibitor to a VHL ligand. This tool compound is useful for probing HDAC4 biology in oncology and neurodegenerative disease research, with efficacy enhanced by co-administration of P-gp inhibitors like Elacridar in certain cell lines.
Molekulargewicht:
1075.26
Formel:
C52H73F3N8O11S
Target-Kategorie:
Others
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
