HDAC4 CHDI Degrader 11 is a potent and selective PROTAC degrader of HDAC4, demonstrating low nanomolar DC50 values in Jurkat and Huntingtons disease model cells. Its bifunctional design links a class IIa HDAC inhibitor to a VHL ligand. This tool compound is useful for probing HDAC4 biology in oncology and neurodegenerative disease research, with efficacy enhanced by co-administration of P-gp inhibitors like Elacridar in certain cell lines.
Molecular Weight:
1075.26
Formula:
C52H73F3N8O11S
Target:
Others
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